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Lgd-4033, like other sarms, is suppressive Administration of opk-88004 suppressed psa in healthy men. A sarm would be particularly attractive in prostate cancer survivors because it could mitigate. Ovarian suppression or removal. Hormonal therapy, also called anti-estrogen therapy, endocrine therapy, or hormone therapy,. The only other sarm that can be more suppressive than rad 140 is yk 11. In theory, sarms should not be suppressive, as you are not supplementing exogenous testosterone. It is not, however, always that clear cut, and sarms users have. The only side effect is, in fact, testosterone suppression, which manifests during long rad-140 cycles (lower mood and libido starting around. Testosterone suppression &amp; estrogen effects. Sarms can suppress the body's natural testosterone production. It may slightly raise blood. Sarms all cause a suppression of the natural production of testosterone. 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